5-MeO-DMT is a potent psychedelic compound belonging to the tryptamine class. Structurally related to DMT and bufotenin, it's renowned for inducing among the most intense psychedelic experiences. 5-MeO-DMT exerts its effects by interacting with serotonin receptors in the brain, though the precise mechanism remains under investigation.

Found in various plant species and the venom of the Incilius alvarius toad, 5-MeO-DMT is believed to have been used in South American shamanic practices for centuries. Today, it's primarily used in synthetic powder form or as toad venom extract, typically administered via vaporization.

Recent studies have shown its capacity to induce profound mystical experiences, and its therapeutic potential is currently being explored.

The subjective effects of 5-MeO-DMT are intense and short-lived, comparable to DMT. However, it often lacks the strong visual distortions characteristic of DMT and instead produces more pronounced physical euphoria and even more powerful transpersonal or mystical-like effects, such as ego dissolution. It has relatively low-toxicity.

5-MeO-DMT can also elicit significant mental and physical side effects, including anxiety, dysphoria, nausea, and bodily discomfort. These effects are often described as challenging and overwhelming.

Given its potency and potential risks, 5-MeO-DMT is generally considered suitable only for experienced users of powerful psychedelics, such as DMT, ayahuasca, and DPT. The importance of harm reduction practices when using this substance cannot be overstated.